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Human Health Exposure Analysis Resource (HHEAR) Study Design Browser

An integral component of the Human Health Exposure Analysis Resource (HHEAR) established by the National Institute of Environmental Health Science (NIEHS), the HHEAR Data Center aims to catalyze new scientific insight from the colocation, integration and advanced statistical and data science analysis of multimodal data sets curated from existing environmental epidemiological research studies.

To benefit the broader research community, the HHEAR Data Center has created a data repository that houses harmonized and de-identified data from all studies accepted into the CHEAR and HHEAR program that have passed an embargo period. The goal of this repository is to promote the secondary analysis of pooled environmental health data by providing data in a manner that is findable, accessible, interoperable and reusable. The repository is searchable by various facets of the studies' design, such as primary health outcome, environmental exposure, and participant life stage. Users are able to compile and download customized datasets from CHEAR and HHEAR research studies.

This site provides the public with a simple Wiki to browse selected design elements and other metadata we have collected for the HHEAR studies.

Studies

• Environmental phenols and pesticide levels in relationship to autism (PI: Bennett, Deborah)
• Maternal and Developmental Risks from Environmental and Social Stressors (MADRES) (PI: Breton, Carrie)
• Mitochondrial DNA biomarkers of prenatal metal mixture exposure: intergenerational inheritance and infant growth (PI: Cardenas, Andres)
• Relating Metals Exposure to Birth and Early Childhood Outcomes via the Metabotype of Cord Blood (PI: Christiani, David)
• Zika Virus Congenital Health Outcomes and the Impact of Maternal Environmental Exposures (PI: Cordero, Jose)
• A Nested Case-Control Study of Prenatal Exposure to Phthalates and Psychosocial Stress: Adverse Pregnancy Outcomes and the Mediating Role of Placental Function (PI: Factor-Litvak, Pam)
• Metabolomics Linking Air Pollution, Obesity and Type 2 Diabetes (PI: Gilliland, Frank)
• First Trimester Exposures: Influence on Birth Outcomes and Markers of Biological Response (PI: Goodrich, Jaclyn)
• ECHO ReCHARGE Study - Environmental Exposures (PI: Hertz-Picciotto, Irva)
• Phthalates and childhood obesity in a racially, ethnically and geographically diverse cohort. (PI: Hunt, Kelly)
• Role of environmental toxicants in modulating disease severity in children with NAFLD (PI: Jain, Ajay)
• SEARCH for Diabetes in Youth (SEARCH) (PI: Jensen, Elizabeth)
• Micronutrient deficiencies, environmental exposures and severe malaria: Risk factors for adverse neurodevelopmental outcomes in Ugandan children (PI: John, Chandy)
• Validation of Detailed Maternal Cigarette Smoke Exposure Self Reporting by Cotinine Analysis (PI: Karagas, Margaret)
• The Dynamics of Exposure, Phthalates and Asthma in a Randomized Trial (DEPART) (PI: Karr, Catherine)
• Evaluation of Environmental Exposures in TEDDY (PI: Krischer, Jeffrey)
• Environmental Toxins in Early Life: Shaping Health and Disease in Childhood (PI: Lasky-Su, Jessica)
• Exposure to metals in pregnant women and the impact on fetal development and birth outcomes in Suriname (PI: Lichtveld, Maureen)
• Denver Asthma Panel Study-CHEAR Ancillary Study (PI: Liu, Andrew)
• Biological Responses to Tobacco Smoke Exposure in Ill Children: Inflammatory Processes and Oral Metabolomic Profiles (PI: Mahabee-Gittens, Melinda)
• Microbial and metabolic variations mediate the influence of childhood and adolescent EDC and trace element exposure on breast density. (PI: Michels, Karen)
• The impact of tobacco smoke exposure and environmental exposures on the pulmonary microbiome and outcomes of critically ill children (PI: Mourani, Peter)
• Sex-Specific Omics Profiles Related to Toxicant Exposures in Children (PI: Perng, Wei)
• Pediatric Inner-City Environmental Exposures at School and Home and Asthma Study (PI: Phipatanakul, Wanda)
• The Role of Environmental Endocrine Disruptors on the Health of Inner City Children (PI: Quiros-Alcala, Lesliam)
• Domestic Indoor PM and Childhood Asthma Morbidity (DISCOVER Study) (PI: Quiros-Alcala, Lesliam)
• Air Pollution, Placenta Function, and Birth Outcomes in Los Angeles (PI: Ritz, Beate)
• Perfluoroalkyl and Polyfluroalkyl Substances (PFAS), Protein Biomarkers, Adiposity and Cardiometabolic Risk Factors in a 3-year Cohort of Low-Income Latino Children with Overweight and Obesity from the Stanford GOALS Randomized Controlled Trial (PI: Robinson, Thomas)
• Perfluoroalkyl substances and lipid composition in human milk (PI: Romano, Megan)
• Internal Metabolomic Biomarker Exposome and Developmental Disorders (IMBEDD) (PI: Schmidt, Rebecca)
• Pesticides, Perfluorinated compounds and the development of adolescents in agricultural communities. (PI: Suarez, Jose)

Biospecimens Analyzed

• blood plasma
• blood serum
• deoxyribonucleic acid
• feces
• milk
• Red Blood Cell
• saliva
• umbilical cord blood
• urine
• Whole Blood

Environmental Exposures

• Alkyl Phosphate Pesticide Metabolite
• Environmental Phenol
• Metal
• Phthalate
• Tobacco Metabolite

Host Institutions

• Boston Children's Hospital
• Brigham and Women's Hospital
• Children's Hospital Colorado
• Cincinnati Children's Hospital Medical Center
• Columbia University
• Dartmouth College
• Geisel School of Medicine
• Harvard Medical School
• Harvard University Department of Global Health and Population
• Indiana University School of Medicine
• Johns Hopkins University
• Medical University of South Carolina
• Saint Louis University Hospital
• Stanford University
• Tulane University
• University of California, Davis
• University of California, Los Angeles
• University of California, San Diego
• University of Colorado Denver
• University of Michigan
• University of South Florida College of Medicine
• University of Southern California
• University of Washington
• Wake Forest University

Life Stages

• Adolescence
• Adult
• Childhood
• Early Childhood
• Maternal Prenatal Stage
• Middle Childhood
• Trans-generational

Primary Health Outcomes

• asthma
• Autism Spectrum Disorder
• cefixime allergy
• cognitive disorder
• diabetes insipidus
• liver disease
• metal metabolism disorder
• obesity